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阿托伐他汀诱发的急性胰腺炎。

Atorvastatin-induced acute pancreatitis.

作者信息

Deshpande Prasanna R, Khera Kanav, Thunga Girish, Hande Manjunath, Gouda Siddalingana T G, Nagappa Anantha Naik

机构信息

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.

出版信息

J Pharmacol Pharmacother. 2011 Jan;2(1):40-2. doi: 10.4103/0976-500X.77114.

DOI:10.4103/0976-500X.77114
PMID:21701646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3117569/
Abstract

Atorvastatin-induced acute pancreatitis (AP) is one of the rare adverse effects available in the literature. We report a case of 53-year-old patient developed AP after treatment with atorvastatin monotherapy which resolved after drug withdrawal. Extensive workup on AP failed to reveal any other etiology for it. To our knowledge, this is one of the rare case reports of AP caused due to atorvastatin monotherapy and it further strengthens the fact that statins may cause AP. There is need of continued reporting of such a rare adverse effect of atorvastatin for increasing awareness and to manage and avoid the same.

摘要

阿托伐他汀所致急性胰腺炎(AP)是文献中记载的罕见不良反应之一。我们报告一例53岁患者,在接受阿托伐他汀单药治疗后发生急性胰腺炎,停药后病情缓解。对该例急性胰腺炎进行的全面检查未发现其他病因。据我们所知,这是阿托伐他汀单药治疗引起急性胰腺炎的罕见病例报告之一,进一步证实了他汀类药物可能导致急性胰腺炎这一事实。需要持续报告阿托伐他汀这种罕见的不良反应,以提高认识并加以处理和避免。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051d/3117569/33f90ff0780b/JPP-2-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051d/3117569/33f90ff0780b/JPP-2-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051d/3117569/33f90ff0780b/JPP-2-40-g001.jpg

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本文引用的文献

1
Atorvastatin-induced pancreatitis.阿托伐他汀诱导的胰腺炎。
Indian J Pharmacol. 2010 Oct;42(5):324-5. doi: 10.4103/0253-7613.70400.
2
Drug-induced acute pancreatitis.药物性急性胰腺炎
Proc (Bayl Univ Med Cent). 2008 Jan;21(1):77-81. doi: 10.1080/08998280.2008.11928366.
3
Statins and pancreatitis: a systematic review of observational studies and spontaneous case reports.他汀类药物与胰腺炎:观察性研究及自发性病例报告的系统评价
Can J Gastroenterol Hepatol. 2020 Nov 3;2020:1516493. doi: 10.1155/2020/1516493. eCollection 2020.
4
Drug induced pancreatitis: A systematic review of case reports to determine potential drug associations.药物性胰腺炎:病例报告的系统回顾,以确定潜在的药物关联性。
PLoS One. 2020 Apr 17;15(4):e0231883. doi: 10.1371/journal.pone.0231883. eCollection 2020.
5
Tamoxifen-induced hypertriglyceridemia causing acute pancreatitis.他莫昔芬诱发的高甘油三酯血症导致急性胰腺炎。
J Pharmacol Pharmacother. 2016 Jan-Mar;7(1):38-40. doi: 10.4103/0976-500X.179365.
6
Atorvastatin Use Associated With Acute Pancreatitis: A Case-Control Study in Taiwan.阿托伐他汀的使用与急性胰腺炎相关:台湾的一项病例对照研究。
Medicine (Baltimore). 2016 Feb;95(7):e2545. doi: 10.1097/MD.0000000000002545.
7
A case of severe acute necrotizing pancreatitis after administration of sitagliptin.一例服用西他列汀后发生的严重急性坏死性胰腺炎。
Clin Med Insights Case Rep. 2013;6:23-7. doi: 10.4137/CCRep.S10856. Epub 2013 Feb 13.
Drug Saf. 2006;29(12):1123-32. doi: 10.2165/00002018-200629120-00004.
4
A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis.一例辛伐他汀相关性胰腺炎及他汀相关性胰腺炎的综述
Pharmacotherapy. 2006 Mar;26(3):414-22. doi: 10.1592/phco.26.3.414.
5
Statins and the risk of acute pancreatitis: a population-based case-control study.他汀类药物与急性胰腺炎风险:一项基于人群的病例对照研究。
Aliment Pharmacol Ther. 2006 Jan 1;23(1):185-90. doi: 10.1111/j.1365-2036.2006.02728.x.
6
Acute pancreatitis associated with combined lisinopril and atorvastatin therapy.赖诺普利与阿托伐他汀联合治疗相关的急性胰腺炎
Dig Dis. 2005;23(1):92-4. doi: 10.1159/000084729.
7
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JOP. 2004 Nov 10;5(6):502-4.
8
Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting.澄清药物不良事件:临床医生术语、记录与报告指南
Ann Intern Med. 2004 May 18;140(10):795-801. doi: 10.7326/0003-4819-140-10-200405180-00009.
9
Acute pancreatitis possibly associated with combined salicylate and atorvastatin therapy.急性胰腺炎可能与水杨酸酯和阿托伐他汀联合治疗有关。
JOP. 2003 Jan;4(1):20-1.
10
[Acute pancreatitis associated with atorvastatine therapy].[阿托伐他汀治疗相关的急性胰腺炎]
Gastroenterol Clin Biol. 2000 Apr;24(4):471-2.