Nakanishi Yukihiro, Akimoto Shingo, Sato Yasuto, Kanai Yae, Sakamoto Michiie, Hirohashi Setsuo
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
Appl Immunohistochem Mol Morphol. 2004 Dec;12(4):323-8. doi: 10.1097/00129039-200412000-00006.
The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently we have reported a novel cell membrane glycoprotein, dysadherin, which has an anti-cell-cell adhesion function and downregulates E-cadherin. Expressions of dysadherin and E-cadherin were investigated immunohistochemically in 91 patients with squamous cell carcinoma of the tongue to determine the correlation between the 2 molecules and their associations with the clinicopathologic features of the tumors and with patient survival. Dysadherin was expressed at the cell membranes of many cancer cells. Twenty-five percent of the tumors showed dysadherin immunopositivity in more than 50% of the cancer cells. Sixty-nine percent of the tumors showed reduced E-cadherin immunopositivity. There was an inverse correlation between dysadherin expression and E-cadherin expression (P = 0.0001). Increased dysadherin expression was significantly correlated with an infiltrative type of growth pattern (P = 0.001), high tumor-node-metastasis (TNM) stage (P = 0.024), and poor patient survival (P = 0.003). After adjusting for growth pattern, TNM stage, and other clinicopathologic features, increased dysadherin expression and reduced E-cadherin expression were both significant predictors of poor survival (P = 0.0006). Increased dysadherin expression is a significant indicator of poor prognosis in patients with squamous cell carcinoma of the tongue.
E-钙黏蛋白介导的细胞黏附系统常因多种机制而失活，并参与多种癌症的肿瘤进展。最近我们报道了一种新型细胞膜糖蛋白——功能障碍黏附素，它具有抗细胞间黏附功能并下调E-钙黏蛋白。对91例舌鳞状细胞癌患者进行免疫组织化学研究，以检测功能障碍黏附素和E-钙黏蛋白的表达，确定这两种分子之间的相关性及其与肿瘤临床病理特征和患者生存率的关系。功能障碍黏附素在许多癌细胞的细胞膜上表达。25%的肿瘤在超过50%的癌细胞中显示功能障碍黏附素免疫阳性。69%的肿瘤显示E-钙黏蛋白免疫阳性降低。功能障碍黏附素表达与E-钙黏蛋白表达呈负相关（P = 0.0001）。功能障碍黏附素表达增加与浸润性生长模式显著相关（P = 0.001）、高肿瘤-淋巴结-转移（TNM）分期（P = 0.024）以及患者生存率低（P = 0.003）。在调整生长模式、TNM分期和其他临床病理特征后，功能障碍黏附素表达增加和E-钙黏蛋白表达降低均是生存率低的显著预测因素（P = 0.0006）。功能障碍黏附素表达增加是舌鳞状细胞癌患者预后不良的重要指标。
