Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Golgasht St., Tabriz, Iran.
Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mol Diagn Ther. 2018 Oct;22(5):523-535. doi: 10.1007/s40291-018-0351-y.
In this study, we systematically investigated and analyzed articles focusing on the prognostic value of E-cadherin (E-cad) in human head and neck squamous cell carcinoma (HNSCC).
Searching through the different databases, the studies examining the associations between E-cad and HNSCC prognosis were identified. Outcomes such as disease-specific survival and overall survival were considered acceptable. Hazard ratio (HR) with 95% confidence interval (CI) was used to demonstrate prognostic value.
A total of 40 studies were systematically analyzed, and finally, 1939 subjects were included in our meta-analysis. Our findings showed that significant aberrant expression of E-cad was associated with poor survival. However, some studies showed increased expression of E-cad in metastatic lesions was associated with poor prognosis. Alteration in location of E-cad expression also showed significant association with cancer survival, i.e., increased cytoplasmic E-cad. We conducted a meta-analysis on the eligible articles using a random effect model because of moderate heterogeneity. Strong association between aberrant expression of E-cad and poor survival was demonstrated (pooled HR = 2.28; 95% CI 1.78-2.91).
Aberrant expression of E-cad may be a promising prognostic signature for HNSCC, especially when it is used with other prognostic markers.
在这项研究中，我们系统地调查和分析了聚焦于 E-钙黏蛋白（E-cad）在人类头颈部鳞状细胞癌（HNSCC）中的预后价值的文章。
通过不同的数据库进行搜索，确定了研究 E-cad 与 HNSCC 预后之间关联的文章。将疾病特异性生存和总生存等结果视为可接受的结果。使用风险比（HR）和 95%置信区间（CI）来展示预后价值。
共系统分析了 40 项研究，最终纳入了 1939 名患者进行荟萃分析。我们的研究结果表明，E-cad 的异常表达与生存不良显著相关。然而，一些研究表明，转移性病变中 E-cad 的高表达与预后不良相关。E-cad 表达位置的改变也与癌症的生存有显著的相关性，即细胞质 E-cad 的增加。由于存在中度异质性，我们对符合条件的文章进行了随机效应模型的荟萃分析。E-cad 的异常表达与不良生存之间存在很强的关联（合并 HR=2.28；95%CI 1.78-2.91）。
E-cad 的异常表达可能是 HNSCC 有前途的预后标志物，特别是与其他预后标志物联合使用时。
