Milleron B
Unité d'Oncologie Pulmonaire, Hôpital Tenon, 4, rue de la Chine, 75020 Paris.
Rev Pneumol Clin. 2004 Nov;60(5 Pt 2):3S11-5.
Bronchial cancer is the ideal candidate for the application of screening strategies: it is a serious, frequent disease and its diagnosis is often delayed. Moreover, only the early stages of the disease offer high hopes of being cured. However, proof of the impact of screening has not been supplied either by X-ray or by cytological examination of expectorations, despite numerous open and subsequent randomised trials. Recently, the low dose scan has shown to be a technique far more sensitive than X-ray and capable of detecting early stage tumours. Nevertheless, it is also a barely specific examination revealing a great number of benign abnormalities and perhaps leading to futile examinations. Because of this, the eventual demonstration of the impact of the scan on the lung cancer mortality warrants the development of randomised trials.
它是一种严重且常见的疾病，其诊断常常被延误。此外，只有疾病的早期阶段才有较高的治愈希望。然而，尽管进行了大量公开及后续的随机试验，但无论是X线检查还是痰液细胞学检查，均未提供筛查有效果的证据。最近，低剂量扫描已被证明是一种远比X线敏感的技术，能够检测出早期肿瘤。然而，它也是一种特异性很差的检查，会显示出大量良性异常，可能导致一些不必要的检查。因此，要最终证明扫描对肺癌死亡率的影响，就有必要开展随机试验。
