Mach N
Service d'oncologie, Département de médecine interne, HUG, 1211 Genève 14.
Rev Med Suisse. 2006 May 17;2(66):1333-4, 1336-7.
Lung cancer is by far the most common cause of death from any tumor. This is partly due to the late stage of most bronchial carcinoma at the time of diagnosis. Curative treatment by surgery is possible only for localized disease. Hope to decrease mortality by screening techniques such as radiography and/or sputum cytology led to several large trials in the eighties. None of these studies were able to show a meaningful decrease in mortality. Improvement in medical imaging lead to a new hope that low-dose CT scan may be an efficient screening tool for lung cancer. This article reviews the data currently available. So far no screening technique has been able to demonstrate an impact on lung cancer mortality despite the higher sensitivity to detect smaller lung tumors. Therefore, in 2006, screening for lung cancer can not be recommended.
肺癌是目前所有肿瘤中最常见的致死原因。部分原因在于大多数支气管癌在诊断时已处于晚期。仅局限性疾病才能通过手术进行根治性治疗。二十世纪八十年代，人们希望通过X线摄影和/或痰细胞学等筛查技术降低死亡率，为此开展了多项大型试验。但这些研究均未能显示死亡率有显著降低。医学成像技术的进步带来了新的希望，即低剂量CT扫描可能是一种有效的肺癌筛查工具。本文回顾了目前可得的数据。尽管检测较小肺部肿瘤的敏感性更高，但迄今为止，尚无筛查技术能够证明对肺癌死亡率有影响。因此，在2006年，不建议进行肺癌筛查。
