Alford Sharon Hensley, Zoratti Edward, Peterson Edward L, Maliarik Mary, Ownby Dennis R, Johnson Christine Cole
The Henry Ford Health System, One Ford Place #5C, Detroit, MI 48202, USA.
J Allergy Clin Immunol. 2004 Nov;114(5):1046-50. doi: 10.1016/j.jaci.2004.08.036.
Family history is an important risk factor for atopic disease. However, most studies assess only limited information on family history. Because atopic disease can exhibit transient or persistent patterns, it may be useful to assess information on patterns of disease within families. This approach has been applied in other diseases, such as cancer, to discriminate between predominantly inherited versus environmentally caused (sporadic) cases.
In a cohort of children who were followed from birth until age 6 to 7 years, we examined the relationship between parental onset (ie, childhood and adulthood) and duration of atopic disease (ie, persistent disease) and the risk of pediatric atopic disease. Our hypothesis was that different parental disease patterns would be important to pediatric risk of disease.
Data from 476 families in the ongoing Childhood Allergy Study in Detroit, Mich, were analyzed by using logistic regression. We examined the association between parental patterns of disease and disease onset in their children. Results Father's disease history, particularly asthma history, was more strongly related to pediatric outcomes than mother's history. Asthma status in the fathers, whether it was childhood-only, adulthood-only, or persistent, was associated with current asthma in the children. Childhood-only and persistent asthma in fathers conferred a higher risk of atopy in the study children, whereas adulthood-only disease did not. There was also a significant relationship between persistent allergy in the father and atopy in the study children.
Our data support the hypothesis that there are complex inheritance patterns for allergy and asthma. Therefore, a detailed family history of atopy, including childhood and adulthood experiences, is critical to identifying and classifying risk and disease phenotypes.
家族病史是特应性疾病的一个重要风险因素。然而，大多数研究仅评估了关于家族病史的有限信息。由于特应性疾病可能呈现短暂或持续的模式，评估家族内疾病模式的信息可能会有所帮助。这种方法已应用于其他疾病，如癌症，以区分主要是遗传引起的病例与环境引起的（散发性）病例。
在一组从出生到6至7岁进行随访的儿童队列中，我们研究了父母发病时间（即儿童期和成年期）与特应性疾病持续时间（即持续性疾病）之间的关系以及儿童患特应性疾病的风险。我们的假设是不同的父母疾病模式对儿童疾病风险很重要。
使用逻辑回归分析了密歇根州底特律正在进行的儿童过敏研究中476个家庭的数据。我们研究了父母疾病模式与其子女疾病发病之间的关联。结果父亲的疾病史，尤其是哮喘病史，比母亲的病史与儿童结局的相关性更强。父亲的哮喘状况，无论是仅儿童期、仅成年期还是持续性的，都与子女当前的哮喘有关。父亲仅儿童期和持续性哮喘使研究儿童患特应性疾病的风险更高，而仅成年期疾病则不然。父亲持续性过敏与研究儿童患特应性疾病之间也存在显著关系。
我们的数据支持过敏和哮喘存在复杂遗传模式的假设。因此，详细的特应性家族病史，包括儿童期和成年期的经历，对于识别和分类风险及疾病表型至关重要。
