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急诊科患者使用补充和替代药物的情况及毒性

Use and toxicity of complementary and alternative medicines among emergency department patients.

作者信息

Taylor David McD, Walsham Nicola, Taylor Simone E, Wong LuFee

机构信息

Department of Emergency Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

出版信息

Emerg Med Australas. 2004 Oct-Dec;16(5-6):400-6. doi: 10.1111/j.1742-6723.2004.00644.x.

Abstract

OBJECTIVE

To determine the prevalence and type of complementary and alternative medicines (CAM) used by ED patients, to identify patient subgroups more likely to use CAM, the conditions for which they were taken, and the prevalence of side-effects and toxicity associated with CAM use.

METHODS

This was an analytical cross-sectional survey of patients at a large tertiary referral ED. Consenting patients completed a specifically designed study questionnaire, in their preferred language if required. Information was collected on CAM use on the day of presentation and within the previous week and previous year.

RESULTS

Four hundred and four patients were enrolled (participation rate 97.1%). Fifty (12.4%, 95% CI 9.4, 16.1) patients had taken a CAM on the day of presentation, 203 (50.2%, 95% CI 45.3, 55.2) within the previous week and 275 (68.1%, 95% CI 63.2, 72.5) within the previous year. CAM users were significantly younger, better educated and more likely to be female than non-CAM users (P < 0.01). 103 different CAM had been taken for a wide variety of reasons. Side-effects were experienced in 53 of the 1182 CAM courses taken (side-effect rate of 4.5%). One patient presented suffering specifically from CAM toxicity.

CONCLUSION

Complementary and alternative medicines are used by a considerable proportion of ED patients. The potential for side-effects, toxicity and interaction with traditional medication indicates the need for consideration of CAM use in patient assessment.

摘要

目的

确定急诊患者使用补充和替代医学(CAM)的患病率及类型,识别更可能使用CAM的患者亚组、使用CAM所针对的病症,以及与使用CAM相关的副作用和毒性的患病率。

方法

这是一项针对大型三级转诊急诊科患者的分析性横断面调查。同意参与的患者完成一份专门设计的研究问卷,如有需要可使用其首选语言。收集了就诊当天、前一周和前一年使用CAM的信息。

结果

共纳入404例患者(参与率97.1%)。50例(12.4%,95%可信区间9.4,16.1)患者在就诊当天使用了CAM,203例(50.2%,95%可信区间45.3,55.2)在前一周使用过,275例(68.1%,95%可信区间63.2,72.5)在前一年使用过。与未使用CAM的患者相比,使用CAM的患者明显更年轻、受教育程度更高且更可能为女性(P<0.01)。出于各种原因使用了103种不同的CAM。在1182次CAM疗程中有53次出现了副作用(副作用发生率为4.5%)。有1例患者出现了专门由CAM毒性导致的症状。

结论

相当一部分急诊患者使用补充和替代医学。其副作用、毒性以及与传统药物相互作用的可能性表明,在患者评估中需要考虑CAM的使用情况。

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