Khan R
McGill University, Faculty of Medicine, 3550 Jeanne Mance, Apt. 1811E, Montreal, Quebec, Canada H2X 3P7.
Cardiovasc Res. 2004 Dec 1;64(3):387-94. doi: 10.1016/j.cardiores.2004.07.025.
The perception of atrial fibrillation development has changed drastically over the last decade. The pulmonary veins have been targeted as the source of arrhythmogenic activity involved in the initiation of atrial fibrillation. This activity appears to be localized in the myocardial sleeves of the vessels. Extensive study of cells within this tissue has helped create a new model for atrial fibrillation. This review attempts to show how the development, architecture and electrophysiologic properties of the pulmonary veins influence the initiation and perpetuation of atrial fibrillation. It also examines the potential long-term effects of pulmonary vein activity on arrhythmia development.
在过去十年中，人们对心房颤动发展的认识发生了巨大变化。肺静脉已被确定为参与心房颤动起始的致心律失常活动的源头。这种活动似乎局限于血管的心肌袖套中。对该组织内细胞的广泛研究有助于建立一个新的心房颤动模型。本综述试图展示肺静脉的发育、结构和电生理特性如何影响心房颤动的起始和持续。它还研究了肺静脉活动对心律失常发展的潜在长期影响。
