Johnell O, Melton L J, Atkinson E J, O'Fallon W M, Kurland L T
Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN 55905.
Age Ageing. 1992 Jan;21(1):32-8. doi: 10.1093/ageing/21.1.32.
In this population-based retrospective cohort study, the 138 Olmsted County, Minnesota residents first diagnosed with Parkinson's disease during 1967-79 were matched by age and sex to an equal number of control subjects from the community. Fractures were assessed through review of each subject's complete (inpatient and outpatient) medical records. At the time of diagnosis, County residents with parkinsonism were no more likely to have a history of selected fractures than control subjects (32% in each group). Subsequently, 33% of cases and 20% of controls experienced one or more new fractures during 696 person-years of follow-up (p = 0.008). The greatest increase in risk was seen for proximal femur fractures, confirming previous case-control studies. By 10 years after diagnosis, an estimated 27% of the parkinsonism cohort had experienced a new hip fracture. The pattern of fractures that was observed suggested that the increased risk was due more to specific types of falls than to disuse osteoporosis.
在这项基于人群的回顾性队列研究中，1967年至1979年间首次被诊断出患有帕金森病的138名明尼苏达州奥姆斯特德县居民，按照年龄和性别与相同数量的社区对照对象进行匹配。通过查阅每个研究对象完整的（住院和门诊）病历对骨折情况进行评估。在诊断时，患有帕金森症的该县居民与对照对象相比，发生特定骨折的病史可能性并无差异（每组均为32%）。随后，在696人年的随访期间，33%的病例组和20%的对照组经历了一次或多次新的骨折（p = 0.008）。股骨近端骨折的风险增加最为显著，这证实了先前的病例对照研究。到诊断后10年，估计27%的帕金森症队列经历了新的髋部骨折。观察到的骨折模式表明，风险增加更多是由于特定类型的跌倒，而非废用性骨质疏松。
