Virmani T, Urbano F J, Bisagno V, Garcia-Rill E
Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Slot 847, Little Rock, AR 72205, USA.
Department of Neurology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
AIMS Neurosci. 2019 Sep 30;6(4):219-230. doi: 10.3934/Neuroscience.2019.4.219. eCollection 2019.
In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
在本综述中，我们首先讨论帕金森病（PD）的一种症状——冻结步态（FOG）的一个例子，然后我们将转向使用对脚桥核（PPN）进行深部脑刺激（DBS）来治疗PD，以及最初导致将PPN确定为运动控制来源之一的研究，以及刺激频率为何至关重要，接着描述PPN神经元的内在特性，这些特性需要β/γ刺激才能完全激活所有类型的PPN神经元。最后，我们将描述关于PPN神经元中γ波段活动的蛋白质组学和分子后果的最新发现，重点是潜在的神经表观遗传后遗症。这些考虑将为适当完善和测试PPN DBS作为PD的潜在治疗方法以及替代方案提供重要信息。
