Liberty Hilary James, Johnson Bruce D, Fortner Neil
National Development and Research Institutes, Inc. (NDRI), 71 West 23rd Street, New York, New York 10010, USA.
J Anal Toxicol. 2004 Nov-Dec;28(8):667-73. doi: 10.1093/jat/28.8.667.
Although urine analysis remains the standard for detection of drugs of abuse, sweat patches provide a convenient alternative that avoids some of the problems with drug testing such as violations of privacy in observed urination, possibility of disease transmission, and transport of noxious fluids. This study examined minimum length of wear necessary to detect recent or concurrent cocaine use in a convenience sample of active cocaine users and also differences in analyte concentrations with increasing longer-term wear. Twenty-seven subjects (22 active drug users and 5 comparison subjects who did not use drugs) wore short-term ((1/2)h, 1 h, 1(1/2) h, and 2 h), then long-term patches (1, 3, 7, and 14 day). Short- and long-term patches were identical except for duration of wear. The predominant analyte found was cocaine, followed by benzoylecgonine, then ecgonine methylester. The minimum duration that patches must be worn to detect recent or concurrent cocaine use in this sample is more than 2 h and less than or equal to 1 day. Analyte concentrations increase significantly with increasing lengths of wear. However, increases between the one-week and two-week patches were significant for benzoylecgonine only.
虽然尿液分析仍是检测滥用药物的标准方法，但汗液贴片提供了一种便捷的替代方法，避免了药物检测中的一些问题，如观察排尿时侵犯隐私、疾病传播的可能性以及有害液体的运输。本研究在一个便利样本中，即活跃的可卡因使用者中，检测近期或同时使用可卡因所需的最短佩戴时长，并研究随着长期佩戴时间增加，分析物浓度的差异。27名受试者（22名活跃吸毒者和5名未吸毒的对照受试者）先佩戴短期贴片（半小时、1小时、1个半小时和2小时），然后佩戴长期贴片（1天、3天、7天和14天）。短期和长期贴片除佩戴时长外完全相同。检测到的主要分析物是可卡因，其次是苯甲酰爱康宁，然后是芽子碱甲酯。在该样本中，要检测近期或同时使用可卡因，贴片必须佩戴的最短时长超过2小时且小于或等于1天。随着佩戴时间延长，分析物浓度显著增加。然而，仅苯甲酰爱康宁在一周和两周贴片之间的增加具有显著性。
