Chawarski Marek C, Fiellin David A, O'Connor Patrick G, Bernard Mathew, Schottenfeld Richard S
Yale University School of Medicine, New Haven, CT 06519, USA.
J Subst Abuse Treat. 2007 Dec;33(4):411-5. doi: 10.1016/j.jsat.2007.03.004. Epub 2007 May 23.
We evaluated the utility of sweat testing for monitoring of drug use in outpatient clinical settings and compared sweat toxicology with urine toxicology and self-reported drug use during a randomized clinical trial of the efficacy of buprenorphine for treatment of opioid dependence in primary care settings. All study participants (N = 63) were opiate-dependent, treatment-seeking volunteers. The results based on toxicology tests obtained from 188 properly worn and unadulterated patches (out of 536 applied) show that the level of agreement between positive sweat test results and positive urine results was 33% for opiates and 92% for cocaine. The findings of this study, that there is a low acceptability of sweat patch testing by patients (only 54.3% were brought back attached to the skin) and that weekly sweat testing is less sensitive than weekly urine testing in detecting opiate use, suggest limited utility of sweat patch testing in outpatient clinical settings.
我们评估了汗液检测在门诊临床环境中监测药物使用情况的效用，并在丁丙诺啡治疗初级保健机构中阿片类药物依赖疗效的随机临床试验期间，将汗液毒理学与尿液毒理学以及自我报告的药物使用情况进行了比较。所有研究参与者（N = 63）均为寻求治疗的阿片类药物依赖志愿者。从536个正确佩戴且未掺假的贴片（共应用了536个）中获得的毒理学测试结果显示，阿片类药物的汗液检测阳性结果与尿液检测阳性结果之间的一致性水平为33%，可卡因的一致性水平为92%。这项研究的结果表明，患者对汗液贴片检测的接受度较低（只有54.3%的贴片被附着在皮肤上带回），并且在检测阿片类药物使用方面，每周的汗液检测不如每周的尿液检测敏感，这表明汗液贴片检测在门诊临床环境中的效用有限。
