Ambre J
J Anal Toxicol. 1985 Nov-Dec;9(6):241-5. doi: 10.1093/jat/9.6.241.
Cocaine plasma levels and urinary excretion data from the literature were subjected to kinetic analysis. The objective was to present the available empirical data in a more useful form and provide a basis for interpretation of cocaine and/or metabolite concentrations in isolated urine samples. Cocaine disposition was modeled as a one-compartment open kinetic system exhibiting linearity within the usually encountered dose range. Model-predicted urine concentrations of cocaine, benzoylecgonine, and ecgonine methyl ester after a 100-mg cocaine dose were compared with literature values to test the validity of the model, and to indicate the use of ratios of concentrations in isolated urine samples to estimate the time since the dose of cocaine. A nomogram relating BZ urine concentrations to cocaine doses was constructed.
对文献中的可卡因血浆水平和尿液排泄数据进行了动力学分析。目的是以更有用的形式呈现现有的经验数据，并为解释孤立尿液样本中的可卡因和/或代谢物浓度提供依据。可卡因处置被建模为一个单室开放动力学系统，在通常遇到的剂量范围内呈现线性。将100毫克可卡因剂量后模型预测的可卡因、苯甲酰芽子碱和芽子碱甲酯尿液浓度与文献值进行比较，以测试模型的有效性，并表明使用孤立尿液样本中浓度的比值来估计自可卡因给药后的时间。构建了一个将尿液中苯甲酰芽子碱浓度与可卡因剂量相关的列线图。
