Zhu De-Zeng
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhong Xi Yi Jie He Xue Bao. 2004 Nov;2(6):412-4. doi: 10.3736/jcim20040603.
Intrahepatic cholestasis results from the disturbance of the structure and function of bile secretory apparatus in hepatic cells. At present, the mechanism of the disease is still not clearly understood. The currently used Western medicine for liver-protective, cholagogic and immuno-suppressive treatment are not effective enough. According to the theory of traditional Chinese medicine, moisture, heat, stasis and toxin are the main factors of the etiology and pathogenesis of the jaundice in patients with intrahepatic cholestasis. Therefore, clearing away heat to drain dampness, cooling blood to remove toxin, activating blood to resolve stasis, soothing liver and invigorating spleen should be adopted in the treatment. In order to increase the therapeutic effects, rational application of traditional Chinese herbs combined with Western medicine should be emphasized in treating the disease under the doctrine of integration of syndrome differentiation and disease differentiation.
肝内胆汁淤积是由肝细胞内胆汁分泌装置的结构和功能紊乱所致。目前，该病的发病机制仍不清楚。目前用于保肝、利胆和免疫抑制治疗的西药疗效不够理想。根据中医理论，湿、热、瘀、毒是肝内胆汁淤积患者黄疸病因病机的主要因素。因此，治疗应采用清热利湿、凉血解毒、活血化瘀、疏肝健脾之法。为提高疗效，在辨证与辨病相结合的原则下，强调中西医结合合理应用中药治疗本病。
