Lewis C G, Fields M, Beal T
Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
J Nutr Biochem. 1990 Mar;1(3):160-6. doi: 10.1016/0955-2863(90)90017-f.
This study was designed to examine the relationship between the fructose-copper interaction and tissue sorbitol concentrations. Weanling male rats were provided with a diet which contained 62.7% fructose and 0.6 microg copper/g (F-Cu) for 4 weeks. At this time, rats were changed to either a fructose diet which contained 6.0 microg copper/g or to a starch diet with or without copper for 2 weeks. When compared with the other dietary groups, it was found that rats fed the F-Cu diet grew poorly; had altered relative liver, pancreatic, heart, and kidney sizes; were anemic; and had higher tissue concentrations of pancreatic and heart glucose, liver, pancreatic, heart, and kidney fructose, and liver, pancreatic, and kidney sorbitol. When rats were changed from the F-Cu diet to one containing copper or to a starch diet with or without copper, weight gain, relative liver, pancreatic and heart sizes, and hematocrit improved significantly. In general, there was a reduction in pancreatic and heart glucose; liver, pancreatic, heart, and kidney fructose; and pancreatic and kidney sorbitol concentrations when rats were changed from the F-Cu diet to any of the other diets. We conclude that the fructose-copper interaction may have a common biochemical basis related to the metabolism of glucose, fructose, and sorbitol.
本研究旨在探讨果糖与铜的相互作用和组织山梨醇浓度之间的关系。给断乳雄性大鼠喂食含62.7%果糖和0.6微克铜/克的饮食（F-Cu），持续4周。此时，将大鼠改为喂食含6.0微克铜/克的果糖饮食或含或不含铜的淀粉饮食，持续2周。与其他饮食组相比，发现喂食F-Cu饮食的大鼠生长不良；肝脏、胰腺、心脏和肾脏的相对大小发生改变；贫血；并且胰腺和心脏葡萄糖、肝脏、胰腺、心脏和肾脏果糖以及肝脏、胰腺和肾脏山梨醇的组织浓度较高。当大鼠从F-Cu饮食改为含铜饮食或含或不含铜的淀粉饮食时，体重增加、肝脏、胰腺和心脏的相对大小以及血细胞比容显著改善。总体而言，当大鼠从F-Cu饮食改为其他任何一种饮食时，胰腺和心脏葡萄糖、肝脏、胰腺、心脏和肾脏果糖以及胰腺和肾脏山梨醇浓度均降低。我们得出结论，果糖与铜的相互作用可能具有与葡萄糖、果糖和山梨醇代谢相关的共同生化基础。
