Bassotti G, Imbimbo B P, Betti C, Dozzini G, Morelli A
Laboratorio di Motilità Intestinale, Università di Perugia, Italy.
Am J Gastroenterol. 1992 Apr;87(4):504-8.
Because little is known about the pathophysiological mechanisms responsible for chronic idiopathic constipation, we studied colon motor response to eating, one of the most physiological and reproducible stimuli, in a clinically homogeneous group of severely constipated subjects. Fifteen patients (14 women, one man) with slow transit constipation (average duration of symptoms 18 +/- 2 yr) entered the study. After colonoscopic positioning of a manometric probe, 2-h basal and 3-h postprandial (1000 kcal standard mixed meal) recordings were obtained. Comparison of tracings with those of 29 healthy volunteers showed that motor response to eating was decreased in constipated subjects. Patients' response was characterized by a shorter duration of contractile activity in all three colon segments studied, after ingestion of the meal, and significantly less high-amplitude propagated contractions (7% vs. 45%). We conclude that several mechanisms are involved in the pathophysiology of colon contractile motor function of patients with chronic idiopathic constipation.
由于对慢性特发性便秘的病理生理机制了解甚少，我们在一组临床特征均一的严重便秘患者中，研究了结肠对进食（最具生理性且可重复性的刺激之一）的运动反应。15例患有慢传输型便秘（症状平均持续时间为18±2年）的患者（14名女性，1名男性）进入了该研究。在通过结肠镜将测压探头定位后，记录了2小时的基础数据以及餐后3小时（1000千卡标准混合餐）的数据。将记录曲线与29名健康志愿者的曲线进行比较后发现，便秘患者对进食的运动反应降低。患者的反应表现为，在所研究的所有三个结肠段中，进食后收缩活动持续时间较短，且高振幅传播性收缩明显较少（分别为7%和45%）。我们得出结论，慢性特发性便秘患者结肠收缩运动功能的病理生理学涉及多种机制。
