Bassotti G, Chiarioni G, Vantini I, Morelli A, Whitehead W E
Z Gastroenterol. 1998 Mar;36(3):209-13.
Erythromycin has been proposed as a therapeutic agent for the treatment of functional motor disorders of the upper gastrointestinal tract. Moreover, some data exist showing a potential effect on colonic motility.
Since no data are available concerning erythromycin effects in chronically constipated patients, we investigated the effects of three different doses of the drug (50, 200, and 500 mg i. v.) on colonic intraluminal pressures in such patients.
18 severely constipated women were studied by a colonoscopically-positioned manometric probe, and were randomized to receive one of three doses of erythromycin. Proximal and distal colonic motility was recorded basally, then during placebo infusion for 60 min and for a further 60 min after the drug had been infused.
Analysis of the tracings showed that, except for the lowest dose in the distal colon, erythromycin failed to stimulate colonic motility in constipated patients.
It is concluded that erythromycin cannot be considered a colokinetic agent, at least at doses commonly employed in the upper gut.
红霉素已被提议作为治疗上消化道功能性运动障碍的药物。此外，有一些数据表明其对结肠动力有潜在影响。
由于尚无关于红霉素对慢性便秘患者影响的数据，我们研究了三种不同剂量的该药物（静脉注射50、200和500毫克）对这类患者结肠腔内压力的影响。
通过结肠镜定位测压探头对18名严重便秘女性进行研究，并将她们随机分为接受三种剂量红霉素中的一种。在基础状态下记录近端和远端结肠动力，然后在输注安慰剂60分钟期间以及输注药物后再60分钟期间进行记录。
对记录的分析表明，除了远端结肠的最低剂量外，红霉素未能刺激便秘患者的结肠动力。
得出的结论是，至少在上消化道常用剂量下，红霉素不能被视为促结肠动力剂。
