Takase Katsunori, Tamagaki Chiharu, Okugawa Gaku, Nobuhara Kenji, Minami Tomohisa, Sugimoto Tatsuya, Sawada Satoshi, Kinoshita Toshihiko
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Neuropsychobiology. 2004;50(4):296-300. doi: 10.1159/000080956.
To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in healthy subjects. There were significant correlations between dosages of neuroleptics during the previous year and absolute gray matter volumes of the caudate nucleus as well as relative white matter volumes in patients with schizophrenia. These findings suggest that reduced white matter volume of the caudate nucleus may be a factor affecting the abnormal connectivity of the corticostriatal loop, and that neuroleptic medication would be related to white matter alteration in patients with schizophrenia. Our result replicates a previous study reporting that there is a lack of negative correlation between age and caudate nucleus volume. We also suggest that the disease process of schizophrenia might interfere with normal aging.
为了检查体积异常情况，利用磁共振成像对精神分裂症患者和健康受试者的尾状核进行了测量。结果发现，与健康受试者相比，精神分裂症患者尾状核中白质的绝对体积和相对体积明显更小。在精神分裂症患者中，前一年的抗精神病药物剂量与尾状核的绝对灰质体积以及相对白质体积之间存在显著相关性。这些发现表明，尾状核白质体积减少可能是影响皮质纹状体环路异常连接的一个因素，并且抗精神病药物治疗与精神分裂症患者的白质改变有关。我们的结果重复了之前一项研究的发现，即年龄与尾状核体积之间不存在负相关。我们还认为，精神分裂症的疾病进程可能会干扰正常衰老。
