Tamagaki Chiharu, Sedvall Göran C, Jönsson Erik G, Okugawa Gaku, Hall Håkan, Pauli Stefan, Agartz Ingrid
Human Brain Informatics, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Am J Psychiatry. 2005 Dec;162(12):2315-21. doi: 10.1176/appi.ajp.162.12.2315.
Anatomical structures of the striatum were studied in 58 patients with schizophrenia and 56 healthy comparison subjects of both genders matched for age and handedness.
Magnetic resonance imaging scans were used to measure gray matter, white matter, and CSF volumes of the caudate, putamen, and nucleus accumbens in the left and the right hemispheres.
White matter/gray matter ratios of the striatal structures were significantly lower in patients than in healthy subjects. In patients, relative white matter volumes in the caudate and nucleus accumbens were reduced, whereas gray matter in the putamen was increased. The total accumbens volume did not differ by diagnosis, but left side accumbens was larger than right in the healthy subjects. The proportion of white matter was greater in women in both the patient and healthy comparison groups. Total caudate and putamen volumes demonstrated no differences due to diagnosis or laterality, but a negative correlation was found in patients between white matter volumes and increasing age. There were no significant correlations among total striatal volumes, white matter/gray matter ratios, age at onset of illness, or illness duration. An estimate of lifetime neuroleptic consumption was positively correlated with right gray matter volume of the putamen in male schizophrenia patients who received typical neuroleptics.
The proportion of white matter to gray matter tissue volumes of the caudate, putamen, and nucleus accumbens is altered in medicated chronic schizophrenia patients, but the total volumes are unchanged.
对58例精神分裂症患者以及56名年龄和利手相匹配的健康对照者的纹状体解剖结构进行研究。
采用磁共振成像扫描测量左右半球尾状核、壳核和伏隔核的灰质、白质及脑脊液体积。
患者纹状体结构的白质/灰质比率显著低于健康受试者。在患者中，尾状核和伏隔核的相对白质体积减小，而壳核的灰质增加。伏隔核总体积在诊断组间无差异，但在健康受试者中左侧伏隔核大于右侧。在患者组和健康对照组中，女性白质比例均更高。尾状核和壳核总体积在诊断组间及左右侧间均无差异，但在患者中白质体积与年龄增长呈负相关。纹状体总体积、白质/灰质比率、起病年龄或病程之间无显著相关性。在接受传统抗精神病药物治疗的男性精神分裂症患者中，终生抗精神病药物使用量估计值与右侧壳核灰质体积呈正相关。
接受药物治疗的慢性精神分裂症患者尾状核、壳核和伏隔核的白质与灰质组织体积比例发生改变，但总体积不变。
