Nanji Amin A, French Samuel W
Department of Pathology, University of Pennsylvania, Philadelphia, USA.
Alcohol Res Health. 2003;27(4):325-30.
The use of animal models has contributed to greater understanding of how alcoholic liver disease (ALD) develops, and of how the severity of liver injury is influenced by factors other than alcohol, such as nutrition, oxygen deprivation (as occurs with sleep apnea or smoking), and gene regulation. This article focuses on the use of one animal model in particular, the intragastric feeding model in rats. This model allows scientists to rigorously control an animal's consumption of both alcohol and dietary nutrients and is providing important information on the mechanisms of injury of alcoholic liver disease.
动物模型的使用有助于更深入地了解酒精性肝病（ALD）的发展过程，以及除酒精外的其他因素（如营养、缺氧（如睡眠呼吸暂停或吸烟时出现的情况）和基因调控）如何影响肝损伤的严重程度。本文特别关注一种动物模型的应用，即大鼠胃内灌喂模型。该模型使科学家能够严格控制动物对酒精和膳食营养素的摄入量，并为酒精性肝病的损伤机制提供重要信息。
