Wei Michael C
Department of Medicine, Children's Hospital Boston, Massachusetts 02125, USA.
Int J Hematol. 2004 Oct;80(3):205-9. doi: 10.1532/ijh97.04110.
The proto-oncogene BCL-2 was discovered with the cloning of the t(14;18) chromosomal translocation responsible for human follicular lymphoma. Since then other members of the Bcl-2 family of cell death regulators have been identified and their roles in cell death, normal lymphoid development, and lymphoid neoplasia have been characterized. Bcl-2 family members are important in tumor initiation, progression, and response to chemotherapy, and altered expression levels of various members serve as prognostic markers in many lymphoid malignancies. There are promising cancer therapeutics now targeted at members of the Bcl-2 family.
原癌基因BCL-2是在克隆导致人类滤泡性淋巴瘤的t(14;18)染色体易位时被发现的。从那时起，细胞死亡调节因子Bcl-2家族的其他成员也被鉴定出来，并且它们在细胞死亡、正常淋巴发育和淋巴瘤形成中的作用也已得到明确。Bcl-2家族成员在肿瘤的起始、进展以及对化疗的反应中都很重要，而且多种成员表达水平的改变在许多淋巴恶性肿瘤中可作为预后标志物。目前有一些很有前景的癌症治疗药物靶向Bcl-2家族成员。
