Kano T, Hashiguchi A, Nakamura M, Morioka T, Mishima M, Nakano M
Department of Anesthesiology, Kumamoto University Hospital, Japan.
Anesth Analg. 1992 Apr;74(4):535-8. doi: 10.1213/00000539-199204000-00012.
The clinical benefits of transdermal 10% lidocaine base gels with and without 3% glycyrrhetinic acid monohemiphthalate disodium (GAMHPh) for reduction of pain at venous cannulation were compared in a randomized, double-blind fashion in 24 surgical patients. After about 60 min of occlusive transdermal application, the mean pinprick pain score (1.3 +/- 1.5) in the GAMHPh group (n = 12), graded by noting the number of painful pinpricks out of five, was significantly less than that (2.5 +/- 1.7) in the control group (n = 12) (P less than 0.05). Twelve patients (eight in the GAMHPh group and four in the control group) who had a pinprick score less than 1 underwent venous cannulation without intradermal injection of a local anesthetic. The pain score at venipuncture, graded by the patients on a scale of 5, was significantly less in the GAMHPh group than that in the control group (1.9 +/- 1.1 vs 3.3 +/- 1.0, P less than 0.05). Erythema observed in 8 of the 24 patients was the only adverse local reaction. Addition of 3% GAMHPh to the lidocaine gel is useful in promoting transdermal lidocaine absorption.
在24例外科手术患者中，采用随机双盲方式比较了含3%甘草次酸单半琥珀酸二钠（GAMHPh）和不含该成分的10%利多卡因碱透皮凝胶在静脉穿刺时减轻疼痛的临床效果。在进行约60分钟的封闭性透皮给药后，GAMHPh组（n = 12）的平均针刺疼痛评分（1.3±1.5，通过记录5次针刺中疼痛针刺的次数进行分级）显著低于对照组（n = 12）（2.5±1.7）（P＜0.05）。12例针刺评分低于1分的患者（GAMHPh组8例，对照组4例）在未皮内注射局部麻醉剂的情况下接受了静脉穿刺。患者对静脉穿刺疼痛的评分（采用5分制）显示，GAMHPh组显著低于对照组（1.9±1.1对3.3±1.0，P＜0.05）。24例患者中有8例出现红斑，这是唯一的局部不良反应。在利多卡因凝胶中添加3%GAMHPh有助于促进透皮利多卡因的吸收。
