Sakamoto M, Kano T, Sadanaga M, Shimoda O, Morioka T, Mishima M, Nakano M
Department of Anaesthesiology, Kumamoto University Hospital, Japan.
Anaesthesia. 1993 May;48(5):390-2. doi: 10.1111/j.1365-2044.1993.tb07010.x.
The analgesic effects of transdermally applied 10% lignocaine aquagel containing 3% glycyrrhetinic acid monohemiphthalate disodium (as an absorption enhancer) and EMLA cream were compared on the forearms of 34 adult volunteers in a double-blind fashion. The mean pinprick pain scores (graded by noting the number of painful pinpricks out of five) at 30, 60 and 90 min after application and 30 min after removal of the anaesthetics were 3.3 (0.3) (mean SE), 1.2 (0.3), 0.3 (0.1) and 0.3 (0.1) respectively, in the lignocaine gel group. Corresponding scores were 3.5 (0.3), 1.5 (0.3), 0.7 (0.2) and 0.1 (0.1) respectively, in the EMLA group. Insertion of a 26-gauge needle into the treated skin to a depth of 1 mm at 90 min after application was not painful in 91% of the volunteers in the lignocaine gel group and 88% of those in the EMLA group. There was no significant difference in any of the corresponding pain scores between the two groups.
采用双盲法，比较了含3%甘草次酸单半酞酸二钠（作为吸收促进剂）的10%利多卡因水凝胶经皮给药与EMLA乳膏对34名成年志愿者前臂的镇痛效果。利多卡因凝胶组在给药后30、60和90分钟以及去除麻醉剂后30分钟的平均针刺疼痛评分（通过记录5次针刺中疼痛针刺的次数进行分级）分别为3.3（0.3）（平均值±标准误）、1.2（0.3）、0.3（0.1）和0.3（0.1）。EMLA组的相应评分分别为3.5（0.3）、1.5（0.3）、0.7（0.2）和0.1（0.1）。给药90分钟后，将26号针头插入治疗皮肤至1毫米深度，利多卡因凝胶组91%的志愿者和EMLA组88%的志愿者均无疼痛感。两组相应疼痛评分之间均无显著差异。
