泽兰属植物中的细胞毒性倍半萜内酯
Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum.
作者信息
Yang N-Y, Qian S-H, Duan J-A, Li P, Tian L-J
机构信息
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
出版信息
J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):339-45. doi: 10.1080/10286020600727673.
Three new germacrane sesquiterpenes, eupalinolides C-E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3beta-acetoxy-8beta-(4'-hydroxytigloyloxy)-14-hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of (1)H and (13)C NMR spectroscopic analysis, including 2D NMR experiments.
从林泽兰中分离出三种新的吉马烷倍半萜，泽兰内酯C - E（1 - 3），以及三种已知的吉马烷倍半萜，泽兰内酯A（4）、泽兰内酯B（5）和3β - 乙酰氧基 - 8β -（4'-羟基惕各酰氧基）- 14 - 羟基木香烯内酯（6）。对它们针对A - 549、BGC - 823、SMMC - 7721和HL - 60肿瘤细胞系进行了细胞毒性测试。结果表明这些化合物表现出较强的细胞毒性。通过（1）H和（13）C NMR光谱分析，包括二维NMR实验，阐明了这些化合物的结构。
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