Chen Zheng W
Department of Microbiology and Immunology & Center for Primate Biomedical Research, University of Illinois, Chicago, Illinois 60612, USA.
Curr HIV Res. 2004 Oct;2(4):351-5. doi: 10.2174/1570162043351147.
While detrimental consequences of biological interaction between HIV and M. tuberculosis are well described, immune mechanisms underlying the evolution of HIV and mycobacterial coinfection remain poorly characterized. Recent studies in HIV-infected humans and SIV-infected monkeys have enhanced our understanding of complex issues of HIV and M. tuberculosis coinfection. Importantly, an anti-viral immune response and an associated control of AIDS virus infection can be induced during coinfection with mycobacterium or other pathogens in HIV-infected humans or SIV-infected monkeys. Restoration of anti-mycobacterial immunity during antiretroviral treatment can contribute to prevention and treatment of AIDS-related mycobacterial diseases. This article discusses recent progress in immune aspects of HIV and mycobacterial coinfection.
虽然HIV与结核分枝杆菌之间生物学相互作用的有害后果已有详尽描述，但HIV与分枝杆菌合并感染演变过程中的免疫机制仍鲜为人知。近期针对HIV感染人类和SIV感染猴子的研究，加深了我们对HIV与结核分枝杆菌合并感染复杂问题的理解。重要的是，在HIV感染人类或SIV感染猴子与分枝杆菌或其他病原体合并感染期间，可诱导抗病毒免疫反应以及对艾滋病病毒感染的相关控制。抗逆转录病毒治疗期间抗分枝杆菌免疫力的恢复有助于预防和治疗艾滋病相关分枝杆菌疾病。本文讨论了HIV与分枝杆菌合并感染免疫方面的最新进展。
