Tsai Wan C, Standiford Theodore J
Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109-0642, USA.
Curr Pharm Des. 2004;10(25):3081-93. doi: 10.2174/1381612043383430.
Macrolide antibiotics appear to play a role in the management of diseases of chronic airway inflammation, distinctly separate from their antibactericidal activity. In the last fifteen years, their success in human clinical trials has prompted both in-vitro and in-vivo investigations to determine the mechanisms by which this family of antibiotics modulate the immune response. A large body of evidence suggests that macrolides directly target multiple components of the inflammatory cascade that occur independent of bactericidal/bacteriostatic effects. We will review the existing data in support of immunomodulatory effects of macrolides on activated leukocytes at the site of lung inflammation, on pulmonary host cells, and in animal models of lung disease.
大环内酯类抗生素似乎在慢性气道炎症疾病的治疗中发挥作用，这与其抗菌活性明显不同。在过去的十五年中，它们在人体临床试验中的成功促使了体外和体内研究，以确定这类抗生素调节免疫反应的机制。大量证据表明，大环内酯类抗生素直接作用于炎症级联反应的多个成分，这些作用独立于杀菌/抑菌作用。我们将综述现有的数据，以支持大环内酯类抗生素对肺部炎症部位活化白细胞、肺宿主细胞以及肺部疾病动物模型的免疫调节作用。
