Takahashi Y, Itoh K, Manabe A, Tani C, Hisamitsu H
Department of Operative Dentistry, Showa University School of Dentistry, Ohta-Ward, Tokyo, Japan.
J Oral Rehabil. 2004 Dec;31(12):1173-7. doi: 10.1111/j.1365-2842.2004.01362.x.
The purpose of this study was to examine the efficacy of experimentally developed high purity glyceryl mono-methacrylate (GM) as a dentine primer and to evaluate the possibility of allergic reaction. The efficacy of experimental dentine primers was evaluated by measuring the polymerization contraction gap width and the tensile bond strength. Allergic reaction was evaluated by the guinea-pig maximization test. The skin reaction was evaluated according to the criteria of the International Contact Dermatitis Research Group. Contraction gap formation was completely prevented and the tensile bond strength was not significantly affected by priming with GM on high-purity GM. The allergic response decreased when high-purity GM was employed as the challenger. It was concluded that the clinical use of the high-purity GM is beneficial as the delayed allergic reaction could be avoided with no detrimental effect on the dentine bonding.
本研究的目的是检测实验研制的高纯度甲基丙烯酸甘油单酯（GM）作为牙本质黏接剂的效果，并评估其发生过敏反应的可能性。通过测量聚合收缩间隙宽度和拉伸黏接强度来评估实验性牙本质黏接剂的效果。通过豚鼠最大化试验评估过敏反应。根据国际接触性皮炎研究组的标准评估皮肤反应。使用高纯度GM进行预处理可完全防止收缩间隙形成，且拉伸黏接强度未受到显著影响。当使用高纯度GM作为激发剂时，过敏反应有所降低。得出的结论是，高纯度GM的临床应用是有益的，因为可以避免迟发性过敏反应，且对牙本质黏接没有不利影响。
