Katsuno K, Manabe A, Itoh K, Nakamura Y, Wakumoto S, Hisamitsu H, Yoshida T
Department of Operative Dentistry, School of Dentistry, Showa University, Tokyo, Japan.
Dent Mater J. 1996 Jun;15(1):22-30. doi: 10.4012/dmj.15.22.
The purposes of this study were to examine whether 2-HEMA, GM, and methacrylic acid cause contact dermatitis, and to determine the optimum concentrations of these primers for sensitization and challenge in guinea pigs. A sensitizing concentration of 0.2% 2-HEMA resulted in strong rubefaction and several vesiculopapules in response to the challenge, and a sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours. We also observed the development of contact dermatitis on human brachia in a closed-patch test. Skin that was treated with both 2-HEMA and GM clearly showed the onset of rubefaction and itchiness. 2-HEMA caused sensitized delayed allergic reactions at all the concentrations tested.
本研究的目的是检测2-甲基丙烯酸羟乙酯（2-HEMA）、明胶（GM）和甲基丙烯酸是否会引起接触性皮炎，并确定这些引发剂在豚鼠致敏和激发试验中的最佳浓度。0.2%的2-HEMA致敏浓度在激发试验后导致强烈的发红和数个水疱丘疹，0.5%的GM致敏浓度在24小时时产生强烈的发红。我们还在封闭斑贴试验中观察了人类上臂接触性皮炎的发生情况。用2-HEMA和GM处理的皮肤明显出现了发红和瘙痒。在所有测试浓度下，2-HEMA都会引起致敏性迟发型过敏反应。
