Katsuno K, Manabe A, Itoh K, Hisamitsu H, Wakumoto S, Nakayama S, Yoshida T
Department of Operative Dentistry, School of Dentistry, Showa University, Japan.
J Dent. 1995 Oct;23(5):295-9. doi: 10.1016/0300-5712(94)00013-6.
This study was undertaken to examine the possibility of a delayed hypersensitivity reaction or contact dermatitis occurring in the guinea-pig in response to methacrylate derivatives used as experimental dentine primers.
The dentine primers 2-HEMA, GM, MA and MMA were tested in a guinea-pig maximization test.
All the dentine primers tested produced positive delayed hypersensitivity reactions in the guinea-pig. MMA produced the most severe reaction.
It is concluded that in the clinical situation, clinicians and other members of the dental team should be aware of the need for careful handling of the dentine primers tested.
本研究旨在探讨豚鼠对用作实验性牙本质黏接剂的甲基丙烯酸酯衍生物发生迟发型超敏反应或接触性皮炎的可能性。
在豚鼠最大化试验中对牙本质黏接剂2-HEMA、GM、MA和MMA进行测试。
所有测试的牙本质黏接剂在豚鼠中均产生了阳性迟发型超敏反应。MMA产生的反应最为严重。
得出结论，在临床情况下，临床医生和牙科团队的其他成员应意识到需要谨慎处理所测试的牙本质黏接剂。
