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减毒活流感疫苗可诱导儿童产生针对类似A/福建/411/2002 H3N2抗原变异株的交叉反应性抗体应答。

Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a/Fujian/411/2002-like H3N2 antigenic variant strain.

作者信息

Mendelman Paul M, Rappaport Ruth, Cho Iksung, Block Stan, Gruber William, August Marilyn, Dawson Denise, Cordova Julie, Kemble George, Mahmood Kutubuddin, Palladino Giuseppe, Lee Min-Shi, Razmpour Ahmad, Stoddard Jeffrey, Forrest Bruce D

机构信息

MedImmune Vaccines, Mountain View, CA, USA.

出版信息

Pediatr Infect Dis J. 2004 Nov;23(11):1053-5. doi: 10.1097/01.inf.0000143643.44463.b1.

DOI:10.1097/01.inf.0000143643.44463.b1
PMID:15545863
Abstract

Serum antibody titers against the A/Panama/2007/99(H3N2) and A/Fujian/411/2002(H3N2)-like viruses were determined in children 6-35 months of age who received either 1 dose of the inactivated influenza vaccine or the live attenuated influenza vaccine containing the A/Panama strain. Results indicated that the live vaccine induced higher antibody responses than the inactivated vaccine against the A/Panama and A/Fujian-like viruses.

摘要

在6至35个月大的儿童中测定了针对A/巴拿马/2007/99(H3N2)和A/福建/411/2002(H3N2)类似病毒的血清抗体滴度，这些儿童接受了一剂灭活流感疫苗或含有A/巴拿马毒株的减毒活流感疫苗。结果表明，与灭活疫苗相比，减毒活疫苗针对A/巴拿马和A/福建类似病毒诱导了更高的抗体反应。

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