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本文引用的文献

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The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.《贝尔蒙报告》。保护人类研究受试者的伦理原则与准则。
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Problems and solutions for circuits and synapses in Parkinson's disease.帕金森病中电路与突触的问题及解决方案
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Nuclear transplantation, embryonic stem cells and the potential for cell therapy.核移植、胚胎干细胞与细胞治疗的潜力。
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Plasticity of adult stem cells.成体干细胞的可塑性。
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Science. 2004 Mar 12;303(5664):1669-74. doi: 10.1126/science.1094515. Epub 2004 Feb 12.
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Human cloning. Scientists take step toward therapeutic cloning.人类克隆。科学家朝着治疗性克隆迈出了一步。
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干细胞：科学、政策与伦理。

Stem cells: science, policy, and ethics.

作者信息

Fischbach Gerald D, Fischbach Ruth L

机构信息

Faculty of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

出版信息

J Clin Invest. 2004 Nov;114(10):1364-70. doi: 10.1172/JCI23549.

DOI:10.1172/JCI23549
PMID:15545983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC525749/
Abstract

Human embryonic stem cells offer the promise of a new regenerative medicine in which damaged adult cells can be replaced with new cells. Research is needed to determine the most viable stem cell lines and reliable ways to promote the differentiation of pluripotent stem cells into specific cell types (neurons, muscle cells, etc). To create new cell lines, it is necessary to destroy preimplantation blastocysts. This has led to an intense debate that threatens to limit embryonic stem cell research. The profound ethical issues raised call for informed, dispassionate debate.

摘要

人类胚胎干细胞为新型再生医学带来了希望，在这种医学中受损的成体细胞可被新细胞替代。需要开展研究以确定最具活力的干细胞系，以及促进多能干细胞分化为特定细胞类型（神经元、肌肉细胞等）的可靠方法。要创建新的细胞系，就有必要破坏植入前的囊胚。这引发了一场激烈的辩论，有可能限制胚胎干细胞研究。所引发的深刻伦理问题需要进行明智、冷静的辩论。