Gilmore John H, Zhai Guihua, Wilber Kathy, Smith J Keith, Lin Weili, Gerig Guido
UNC Schizophrenia Research Center, University of North Carolina, Chapel Hill, NC 27599-7160, USA.
Psychiatry Res. 2004 Nov 15;132(1):81-5. doi: 10.1016/j.pscychresns.2004.04.004.
While it has been hypothesized that brain development is abnormal in schizophrenia and other neurodevelopmental disorders, there have been few attempts to study very early brain development in children. Twenty unsedated healthy newborns underwent 3 Tesla magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI). The left ventricle was significantly larger than the right; females had significantly larger ventricles than males. Fractional anisotropy (FA) increased significantly with gestational age in the genu and splenium of the corpus callosum. It is feasible to study brain development in unsedated newborns using 3 T MRI.
虽然有假说认为精神分裂症和其他神经发育障碍患者的大脑发育异常，但很少有人尝试研究儿童极早期的大脑发育情况。20名未使用镇静剂的健康新生儿接受了3特斯拉磁共振成像（MRI）检查，包括扩散张量成像（DTI）。左心室明显大于右心室；女性的心室明显大于男性。胼胝体膝部和压部的各向异性分数（FA）随胎龄显著增加。使用3T MRI研究未使用镇静剂的新生儿大脑发育是可行的。
