Kalinowski Douglas P, Edsberg Laura E, Hewson Robert A, Johnson Robert H, Brogan Michael S
Department of Natural Sciences, Daemen College, 4380 Main St, Amherst, NY 14226, USA.
J Am Podiatr Med Assoc. 2004 Nov-Dec;94(6):565-72. doi: 10.7547/0940565.
Onychomycosis, most commonly caused by two species of dermatophyte fungi--Trichophyton rubrum and Trichophyton mentagrophytes--is primarily treated with regimens of topical and systemic antifungal medications. This study was undertaken to evaluate in vitro the efficacy of low-voltage direct current as an antifungal agent for treating onychomycosis. Agar plate cultures of T rubrum and T mentagrophytes were subjected to low-voltage direct current electrostimulation, and antifungal effects were observed as zones in the agar around the electrodes lacking fungal growth. Zones devoid of fungal growth were observed for T rubrum and T mentagrophytes around anodes and cathodes in a dose-dependent manner in the current range of 500 microA to 3 mA. Low-voltage direct current electrostimulation has great clinical potential for the treatment of onychomycosis and perhaps other superficial maladies of fungal etiology.
甲癣最常见由两种皮肤癣菌——红色毛癣菌和须癣毛癣菌引起，主要通过局部和全身抗真菌药物治疗方案进行治疗。本研究旨在体外评估低压直流电作为治疗甲癣的抗真菌剂的疗效。对红色毛癣菌和须癣毛癣菌的琼脂平板培养物进行低压直流电电刺激，并将抗真菌效果观察为电极周围琼脂中无真菌生长的区域。在500微安至3毫安的电流范围内，红色毛癣菌和须癣毛癣菌在阳极和阴极周围均观察到无真菌生长的区域，且呈剂量依赖性。低压直流电电刺激在治疗甲癣以及可能的其他真菌病因引起的浅表疾病方面具有巨大的临床潜力。
