RNA扭结向左和向右弯曲。
RNA kink turns to the left and to the right.
作者信息
Strobel Scott A, Adams Peter L, Stahley Mary R, Wang Jimin
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave., New Haven, CT 06520-8114, USA.
出版信息
RNA. 2004 Dec;10(12):1852-4. doi: 10.1261/rna.7141504.
Abstract
A helix-loop-helix within the group I intron has most of the canonical sequence elements of a kink turn (K-turn), yet it bends in the opposite direction. The reverse K-turn kinks toward the major rather than the minor grooves of the flanking helices. This suggests that there are two distinct subclasses of tertiary structures that a K-turn secondary structure can adopt. The final structure may be specified by external factors, such as protein binding or the tertiary structural context, rather than the intrinsic conformation of the RNA.
摘要
I 组内含子中的一个螺旋-环-螺旋具有扭结转角（K-turn）的大部分典型序列元件，但它向相反方向弯曲。反向 K-turn 向侧翼螺旋的大沟而非小沟扭结。这表明 K-turn 二级结构可以采用两种不同的三级结构亚类。最终结构可能由外部因素决定，如蛋白质结合或三级结构背景，而非 RNA 的固有构象。
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