皮肤斑贴试验在诊断特应性皮炎儿童食物过敏中的作用。

Role of the skin patch test in diagnosing food allergy in children with atopic dermatitis.

作者信息

Rokaite Rūta, Labanauskas Liutauras, Vaideliene Laimute

机构信息

KMUK Vaiku ligu klinika, Eiveniu 2, 50009 Kaunas, Lithuania.

出版信息

Medicina (Kaunas). 2004;40(11):1081-7.

PMID:15547309

Abstract

UNLABELLED

The aim of the study was to determine peculiarities of food allergy in children with atopic dermatitis and to evaluate the significance of skin patch test in determining the main food allergens.

METHODS

One hundred and eight children (57 boys and 51 girls) with atopic dermatitis were examined. Atopic dermatitis was diagnosed by standard diagnostic criteria, severity of the progress of the disease was determined using SCORAD index and the amount of total IgE in blood, skin prick and patch tests with the main food allergens were performed.

RESULTS

The age of the patients varied from 6 months to 16 years, however, almost half (41%) of them were toddlers (1-3 years old). Mild form of atopic dermatitis was dominating (52%). Analysis of the total IgE amount in blood showed different degree of sensitivity of the children tested. Normal amount of the total IgE in blood was found in 73.1% of children with atopic dermatitis, and the increased total IgE amount was found only in 26.9% of children. Positive skin prick test with the standard and the most common food allergens was found only in 4.63% of children with atopic dermatitis, while the positive skin patch test with 25 food allergens was found in 68.5% of children. Depending on the type of the allergic reaction, immediate type reaction dominated only in 10.3% of children with atopic dermatitis, while the delayed type allergic reactions were characteristic to food allergies in 48.3% of children with atopic dermatitis. Food allergy was not found in one fifth of children with atopic dermatitis.

CONCLUSIONS

Skin patch test is an informative and reliable diagnostic test in evaluating the delayed type allergic reactions. In about half of the tested persons with atopic dermatitis, food allergy appeared in delayed type allergic reactions. Therefore it is very important to do the skin patch test for toddlers and pre-school age children. The most common allergens found with the help of skin patch test are soy, milk, peanuts, carrot, egg whites, wheat, and corn.

摘要

未标注

本研究的目的是确定特应性皮炎患儿食物过敏的特点，并评估皮肤斑贴试验在确定主要食物过敏原方面的意义。

方法

对108例特应性皮炎患儿（57例男孩和51例女孩）进行检查。特应性皮炎采用标准诊断标准进行诊断，使用SCORAD指数确定疾病进展的严重程度，并检测血液中总IgE的含量，对主要食物过敏原进行皮肤点刺试验和斑贴试验。

结果

患者年龄从6个月至16岁不等，然而，其中近一半（41%）为幼儿（1 - 3岁）。轻度特应性皮炎占主导（52%）。血液中总IgE含量分析显示受试儿童的敏感程度不同。73.1%的特应性皮炎患儿血液中总IgE含量正常，仅26.9%的患儿总IgE含量升高。特应性皮炎患儿中仅4.63%对标准及最常见食物过敏原的皮肤点刺试验呈阳性，而对25种食物过敏原的皮肤斑贴试验68.5%呈阳性。根据过敏反应类型，速发型反应仅在10.3%的特应性皮炎患儿中占主导，而迟发型过敏反应在48.3%的特应性皮炎患儿食物过敏中较为典型。五分之一的特应性皮炎患儿未发现食物过敏。