Vaiserman Alexander M, Koshel Natalya M, Mechova Ludmila V, Voitenko Vladimir P
Laboratory of Mathematical Modelling of Aging Processes, Institute of Gerontology, Vyshgorodskaya st. 67, Kiev 04114, Ukraine.
Biogerontology. 2004;5(5):327-37. doi: 10.1007/s10522-004-2571-2.
The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and increased locomotor (photo- and geotactic) activity, whereas metabolic rate measured as the rate of CO2 production was unchanged or even increased, and female fecundity was slightly reduced compared to appropriate controls. In some cases, irradiation resulted in hormetic effects increased resistance to both starvation and heat shock stresses as well as life extension. An explanation of the beneficial long lasting effects induced by early irradiation is offered, which suggests that these effects are due to cross-life stage and cross-generational adaptive phenotypic plasticity.
研究了用0.25、0.5、0.75和1戈瑞的X射线对1小时龄果蝇卵进行照射，对成年黑腹果蝇及其后代与适应性相关的生活史特征的长期影响。在用0.25、0.5和0.75戈瑞照射后，F0和F1代果蝇的成虫体重均下降，运动（趋光和趋地）活性增加，而以二氧化碳产生速率衡量的代谢率未发生变化甚至有所增加，与相应对照组相比，雌蝇的繁殖力略有降低。在某些情况下，照射会产生应激效应，增强对饥饿和热休克应激的抵抗力，并延长寿命。本文对早期照射诱导的有益长期效应给出了解释，表明这些效应是由于跨生命阶段和跨代适应性表型可塑性所致。
