Lin Yinling, Roberts Tonya J, Spence Philip M, Brutkiewicz Randy R
Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute, Indianapolis, IN 46202-5181, USA.
J Leukoc Biol. 2005 Feb;77(2):151-8. doi: 10.1189/jlb.0704399. Epub 2004 Nov 17.
Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (MPhi) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and MPhi was independent of interferon-gamma and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.
用淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染小鼠，以确定在急性病毒感染期间CD1d表达是否发生变化。有趣的是，在LCMV感染后至少3个月观察到脾树突状细胞（DC）和巨噬细胞（MPhi）上CD1d表达降低，并且痘苗病毒和水疱性口炎病毒感染后也诱导了CD1d的类似变化。DC和MPhi上CD1d细胞表面表达的降低与干扰素-γ和白细胞介素-12表达无关，但在与抗原加工相关的转运体1缺陷小鼠中部分恢复，这表明CD8 + T细胞可能起作用。因此，细胞免疫反应诱导的一个后果是CD1d表达的变化，这可能是调节抗病毒免疫的关键因素。
