幼鼠的记忆巩固和再巩固需要蛋白质合成。
Memory consolidation and reconsolidation in the rat pup require protein synthesis.
作者信息
Gruest Nadège, Richer Paulette, Hars Bernard
机构信息
Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire, et de la Communication, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8620, Université Paris-sud, 91405 Orsay Cedex, France.
出版信息
J Neurosci. 2004 Nov 17;24(46):10488-92. doi: 10.1523/JNEUROSCI.2984-04.2004.
Abstract
Little is known about the ontogenesis of memory, whether it appears with its full characteristics or whether they emerge progressively with development. In the adult, basic characteristics of memory processing are consolidation of memory after acquisition and reconsolidation after retrieval. Here, using a conditioned aversion paradigm and postlearning or postreactivation injection of a protein synthesis inhibitor, we show that memory acquired by rat pups as early as postnatal day 3 requires time-dependent protein synthesis after both learning and reactivation. These results present the first evidence suggesting that consolidation and reconsolidation are original properties of memory function.
摘要
关于记忆的个体发生，我们所知甚少，即记忆是一开始就以其全部特征出现，还是随着发育逐渐显现。在成体中，记忆处理的基本特征是习得后记忆巩固以及提取后再巩固。在此，我们利用条件性厌恶范式以及在学习后或再激活后注射蛋白质合成抑制剂，发现早在出生后第3天的大鼠幼崽所获得的记忆，在学习和再激活后都需要时间依赖性蛋白质合成。这些结果首次证明，巩固和再巩固是记忆功能的原始特性。
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