Eisenberg Mark, Kobilo Tali, Berman Diego E, Dudai Yadin
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
Science. 2003 Aug 22;301(5636):1102-4. doi: 10.1126/science.1086881.
In memory consolidation, the memory trace stabilizes and becomes resistant to certain amnesic agents. The textbook account is that for any memorized item, consolidation starts and ends just once. However, evidence has accumulated that upon activation in retrieval, the trace may reconsolidate. Whereas some authors reported transient renewed susceptibility of retrieved memories to consolidation blockers, others could not detect it. Here, we report that in both conditioned taste aversion in the rat and fear conditioning in the medaka fish, the stability of retrieved memory is inversely correlated with the control of behavior by that memory. This result may explain some conflicting findings on reconsolidation of activated memories.
在记忆巩固过程中，记忆痕迹会稳定下来，并对某些失忆剂产生抗性。教科书上的说法是，对于任何记忆项目，巩固过程只开始和结束一次。然而，越来越多的证据表明，在检索过程中被激活时，记忆痕迹可能会重新巩固。虽然一些作者报告说，检索到的记忆对巩固阻滞剂的敏感性会短暂恢复，但另一些作者却未能检测到这一点。在这里，我们报告，在大鼠的条件性味觉厌恶和青鳉鱼的恐惧条件反射中，检索到的记忆的稳定性与该记忆对行为的控制呈负相关。这一结果可能解释了关于激活记忆再巩固的一些相互矛盾的发现。
