Metelitsina T I, Grunwald J E, DuPont J C, Ying G-S
Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA.
Br J Ophthalmol. 2004 Dec;88(12):1568-72. doi: 10.1136/bjo.2004.046607.
To investigate the effects of niacin on choroidal blood flow in age related macular degeneration (AMD).
12 AMD patients with bilateral drusen and visual acuity of 20/40 or better in the study eye received a single oral dose of niacin (six subjects received 500 mg and six received 250 mg) or matching placebo on two separate occasions. Laser Doppler flowmetry was used to assess relative choroidal blood velocity (ChB(Vel)), volume (ChB(Vol)), and flow (ChB(Flow)) in the foveola of the study eye at baseline, 30, and 90 minutes after dosing.
In comparison with placebo, a statistically significant 24% increase in ChB(Vol) was observed 30 minutes after niacin administration (ANOVA, p = 0.01). In comparison with placebo, a significant decrease in ChB(Vel) of 23% was observed in the 500 mg group (p = 0.04) and no significant change in ChB(Vel) was seen in the 250 mg group at 30 minutes. No significant changes in ChB(Flow) were detected at 30 or 90 minutes. Also, there were no statistically significant changes in ChB(Vol) or ChB(Vel) at 90 minutes.
In comparison with placebo, a significant 24% increase in ChB(Vol) was observed 30 minutes after niacin administration. Owing to simultaneous decrease in ChB(Vel), however, no significant change in ChB(Flow) was detected.
研究烟酸对年龄相关性黄斑变性（AMD）脉络膜血流的影响。
12例双眼患有玻璃膜疣且研究眼视力为20/40或更好的AMD患者，在两个不同时间分别接受单次口服烟酸（6例接受500毫克，6例接受250毫克）或匹配的安慰剂。在给药前、给药后30分钟和90分钟，使用激光多普勒血流仪评估研究眼黄斑中心凹处的相对脉络膜血流速度（ChB(Vel)）、血容量（ChB(Vol)）和血流量（ChB(Flow)）。
与安慰剂相比，烟酸给药后30分钟观察到ChB(Vol)有统计学意义的24%增加（方差分析，p = 0.01）。与安慰剂相比，500毫克组在30分钟时ChB(Vel)显著降低23%（p = 0.04），250毫克组在30分钟时ChB(Vel)未见显著变化。在30分钟或90分钟时未检测到ChB(Flow)有显著变化。此外，90分钟时ChB(Vol)或ChB(Vel)也无统计学意义的变化。
与安慰剂相比，烟酸给药后30分钟观察到ChB(Vol)显著增加24%。然而，由于ChB(Vel)同时降低，未检测到ChB(Flow)有显著变化。
