Beachy Philip A, Karhadkar Sunil S, Berman David M
Department of Molecular Biology and Genetics, The Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA.
Nature. 2004 Nov 18;432(7015):324-31. doi: 10.1038/nature03100.
Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a minority of cells with stem-cell-like properties and in its possible derivation from normal tissue stem cells. But stem cell activity is tightly controlled, raising the question of how normal regulation might be subverted in carcinogenesis. The long-known association between cancer and chronic tissue injury, and the more recently appreciated roles of Hedgehog and Wnt signalling pathways in tissue regeneration, stem cell renewal and cancer growth together suggest that carcinogenesis proceeds by misappropriating homeostatic mechanisms that govern tissue repair and stem cell self-renewal.
癌症越来越被视为一种干细胞疾病，这体现在它由少数具有干细胞样特性的细胞进行增殖，以及它可能源自正常组织干细胞。但是干细胞活性受到严格控制，这就引发了一个问题，即在致癌过程中正常调节是如何被颠覆的。癌症与慢性组织损伤之间长期存在的关联，以及刺猬信号通路和Wnt信号通路最近在组织再生、干细胞更新和癌症生长中所发挥的作用，共同表明致癌作用是通过挪用控制组织修复和干细胞自我更新的稳态机制来进行的。
