Becker Christoph R, Majeed Amal, Crispin Alexander, Knez Andreas, Schoepf U Joseph, Boekstegers Peter, Steinbeck Gerhard, Reiser Maximilian F
Department of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany.
Eur Radiol. 2005 Jan;15(1):96-101. doi: 10.1007/s00330-004-2528-5. Epub 2004 Nov 10.
Coronary calcium mass percentiles can be derived from electron beam CT as well as from multidetector-row CT of all manufacturers. Coronary calcium mass may serve as a more individualized substitute for age for cardiac risk stratification. The aim was to investigate the potential impact of CT coronary calcium mass quantification on cardiac risk stratification using an adjusted Framingham score. Standardized coronary calcium mass was determined by multidetector-row CT in a total of 1,473 patients (1,038 male, 435 female). The impact on risk stratification of replacing the traditional Framingham age point score by a point score based on calcium mass relative to age was tested. Any coronary calcium found in males in the age group of 20-34 years and females in the age group of 20-59 years results in an increase of the Framingham score by 9 and 4-7 points, respectively. Only in males 65 years of age and older, none or minimal amounts of coronary calcium decrease the Framingham score by three points. The coronary calcium mass and age-related scoring system may have impact on the reassignment of patients with an intermediate Framingham risk to a lower or higher risk group.
冠状动脉钙质量百分位数可通过电子束CT以及所有制造商的多排探测器CT得出。冠状动脉钙质量可作为心脏风险分层中更具个性化的年龄替代指标。目的是使用调整后的弗雷明汉评分来研究CT冠状动脉钙质量量化对心脏风险分层的潜在影响。通过多排探测器CT对总共1473例患者（1038例男性，435例女性）测定标准化冠状动脉钙质量。测试了用基于钙质量相对于年龄的评分来取代传统弗雷明汉年龄评分对风险分层的影响。在20 - 34岁年龄组的男性和20 - 59岁年龄组的女性中，发现任何冠状动脉钙都会使弗雷明汉评分分别增加9分和4 - 7分。仅在65岁及以上的男性中，无冠状动脉钙或极少量冠状动脉钙会使弗雷明汉评分降低3分。冠状动脉钙质量和与年龄相关的评分系统可能会对将具有中等弗雷明汉风险的患者重新分类到较低或较高风险组产生影响。
