Gessi Marco, Marani Carla, Geddes Jennian, Arcella Antonella, Cenacchi Giovanna, Giangaspero Felice
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy.
Acta Neuropathol. 2005 Feb;109(2):231-4. doi: 10.1007/s00401-004-0927-y. Epub 2004 Nov 12.
We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.
我们描述了一例具有神经毡样岛状神经元分化形式的室管膜瘤。一名6岁男孩因头痛和呕吐病史较短而接受临床检查。脑部计算机断层扫描显示顶枕部有一个大的、部分囊性病变。肿瘤由呈血管周围排列的胶质纤维酸性蛋白阳性圆形细胞和散在的神经毡样岛状结构组成，突触素呈强阳性。尽管进行了放疗，肿瘤仍复发，表现出明显的间变特征，但缺乏神经毡样岛状结构。根据不同谱系的胶质瘤偶尔可发生神经元分化而不影响预期生物学行为这一概念，对肿瘤的组织学特征进行了讨论。
