Woelfle Joachim, Chia Dennis J, Massart-Schlesinger Mylynda B, Moyano Paula, Rotwein Peter
Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.
Pediatr Nephrol. 2005 Mar;20(3):295-302. doi: 10.1007/s00467-004-1602-1. Epub 2004 Nov 10.
Since the somatomedin hypothesis of growth hormone (GH) action was first formulated nearly 50 years ago, the key roles of both GH and insulin-like growth factor (IGF)-I in human growth have been confirmed and extended to include local effects on tissue maintenance and repair. More recent insights have revealed a dark side to the GH/IGF-I signaling system. Both proteins have been implicated as potential contributing factors in selected human cancers, and normal activity through this signaling pathway has been linked to diminished lifespan in experimental animals. This review highlights both the positive and negative aspects of the GH/IGF-I-growth pathway. The overall goal is to reinforce the need for more complete understanding of the mechanisms of signaling and action of GH and IGF-I, in order to separate, if possible, the potentially beneficial outcomes on growth and on tissue maintenance and repair from deleterious effects on cancer risk and lifespan.
自近50年前首次提出生长激素（GH）作用的生长调节素假说以来，GH和胰岛素样生长因子（IGF）-I在人类生长中的关键作用已得到证实，并扩展到包括对组织维持和修复的局部作用。最近的研究揭示了GH/IGF-I信号系统的阴暗面。这两种蛋白质都被认为是某些人类癌症的潜在促成因素，并且通过该信号通路的正常活性与实验动物寿命缩短有关。本综述强调了GH/IGF-I-生长途径的积极和消极方面。总体目标是加强对GH和IGF-I信号传导和作用机制进行更全面理解的必要性，以便尽可能将对生长、组织维持和修复的潜在有益结果与对癌症风险和寿命的有害影响区分开来。
