Paulus K S, Magnano I, Conti M, Galistu P, D'Onofrio M, Satta W, Aiello I
Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, I-07100, Sassari, Italy.
Neurol Sci. 2004 Oct;25(4):220-4. doi: 10.1007/s10072-004-0325-1.
Cerebellar pathology commonly shows important motor signs and less evident cognitive dysfunction. The 'cerebellar cognitive affective syndrome' is characterised by impairment on executive function, spatial cognition, language and behaviour. We report the case of a man with acute onset of transitory motor features and severe mental disorders. Cranial CT and brain MRI revealed extended cerebellar lesions. Neuropsychological assessment disclosed deficits of attention, executive function and memory. Auditory event-related potentials showed abnormal P300. These data suggest a pure "cerebellar cognitive affective syndrome"and strengthen the hypothesis of cerebellar cognitive function modulation.
小脑病变通常表现为重要的运动体征和不太明显的认知功能障碍。“小脑认知情感综合征”的特征是执行功能、空间认知、语言和行为受损。我们报告了一例急性起病的短暂性运动特征和严重精神障碍的男性病例。头颅CT和脑部MRI显示小脑病变范围扩大。神经心理学评估发现注意力、执行功能和记忆方面存在缺陷。听觉事件相关电位显示P300异常。这些数据提示存在单纯的“小脑认知情感综合征”，并强化了小脑认知功能调节的假说。
