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小脑卒中后认知功能障碍:神经心理学和神经影像学研究的新见解。

Cognitive Dysfunction following Cerebellar Stroke: Insights Gained from Neuropsychological and Neuroimaging Research.

机构信息

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

出版信息

Neural Plast. 2022 Apr 15;2022:3148739. doi: 10.1155/2022/3148739. eCollection 2022.

Abstract

Although the cerebellum has been consistently noted in the process of cognition, the pathophysiology of this link is still under exploration. Cerebellar stroke, in which the lesions are focal and limited, provides an appropriate clinical model disease for studying the role of the cerebellum in the cognitive process. This review article targeting the cerebellar stroke population (1) describes a cognitive impairment profile, (2) identifies the cerebellar structural alterations linked to cognition, and (3) reveals possible mechanisms of cerebellar cognition using functional neuroimaging. The data indicates the disruption of the cerebro-cerebellar loop in cerebellar stroke and its contribution to cognitive dysfunctions. And the characteristic of cognitive deficits are mild, span a broad spectrum, dominated by executive impairment. The consideration of these findings could contribute to deeper and more sophisticated insights into the cognitive function of the cerebellum and might provide a novel approach to cognitive rehabilitation. The goal of this review is to spread awareness of cognitive impairments in cerebellar disorders.

摘要

虽然小脑在认知过程中一直被注意到,但这一联系的病理生理学仍在探索之中。小脑卒中,病变是局灶性和有限的,为研究小脑在认知过程中的作用提供了一个适当的临床模型疾病。这篇针对小脑卒中人群的综述文章(1)描述了认知障碍的特征,(2)确定了与认知相关的小脑结构改变,(3)利用功能神经影像学揭示了小脑认知的可能机制。数据表明小脑卒中破坏了脑-小脑循环,并导致认知功能障碍。而且认知缺陷的特点是轻微的,范围广泛,以执行功能障碍为主。考虑到这些发现,可以更深入、更复杂地了解小脑的认知功能,并可能为认知康复提供一种新方法。本综述的目的是提高对小脑疾病认知障碍的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/9033331/44dc80e530c2/NP2022-3148739.001.jpg

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