Iurlaro S, Beghi E, Massetto N, Guccione A, Autunno M, Colombo B, Di Monda T, Gionco M, Cortelli P, Perini F, D'Onofrio F, Agostoni E
Stroke Unit, Centro Cefalee, Clinica Neurologica, Università degli Studi Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, I-20052 Monza (MI), Italy.
Neurol Sci. 2004 Oct;25 Suppl 3:S298-9. doi: 10.1007/s10072-004-0317-1.
The main aim of this study is to look for early clinical markers of cerebral venous thrombosis (CVT). As headache represents the major clinical manifestation at presentation we focused our attention on this symptom. We present the preliminary results of a prospective multicentric study that includes cases diagnosed as CVT in the participating centres. We have so far studied 35 patients (5 males and 30 females) from the ages of 18 to 78. The most frequent manifestation was headache (77.1%). It was more frequently localised (66.7%) and continuous (77.8%). The onset of pain was mostly acute-subacute (38.5%-50.0%) and the intensity moderate-severe (37.0%-51.9%). On univariate analysis, we found a positive correlation between CVT, acute headache onset (p=0.001) and severe headache (p=0.004). These preliminary results seem in accordance with our previous findings in the retrospective study, suggesting that CVT is more often associated with acute-onset headache of severe intensity.
本研究的主要目的是寻找脑静脉血栓形成（CVT）的早期临床标志物。由于头痛是发病时的主要临床表现，我们将注意力集中在这一症状上。我们展示了一项前瞻性多中心研究的初步结果，该研究纳入了参与中心诊断为CVT的病例。到目前为止，我们研究了35例患者（5例男性和30例女性），年龄在18至78岁之间。最常见的表现是头痛（77.1%）。头痛更常局限于局部（66.7%）且为持续性（77.8%）。疼痛发作大多为急性-亚急性（38.5%-50.0%），强度为中度-重度（37.0%-51.9%）。单因素分析显示，我们发现CVT与急性头痛发作（p=0.001）和重度头痛（p=0.004）之间存在正相关。这些初步结果似乎与我们之前在回顾性研究中的发现一致，表明CVT更常与重度强度的急性发作头痛相关。
