Kligman A M
Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia.
Drugs Aging. 1992 Jan-Feb;2(1):7-13. doi: 10.2165/00002512-199202010-00002.
In 1986, an open study was published which showed that tretinoin 0.05% applied topically to actinically damaged skin could partially reverse the clinical and histological signs of photoaging. These results stimulated other investigators to examine the effects of tretinoin on photodamaged, prematurely aged skin. Double-blind controlled studies in the United States and Europe have confirmed the original claims. Side effects have been limited to a variable irritant reaction (dryness, tightness, erythema) that subsides as the treated skin accommodates. Physicians must counsel patients to have realistic expectations; tretinoin is not a substitute for plastic surgery. Tretinoin is the centrepiece of a treatment programme which includes regular use of sunscreens and moisturisers along with avoidance of harmful behaviours, such as smoking, use of abrasives, and excessive washing.
1986年，一项公开研究发表，该研究表明，将0.05%的维甲酸局部应用于光化性损伤皮肤，可部分逆转光老化的临床和组织学特征。这些结果促使其他研究人员研究维甲酸对光损伤、过早老化皮肤的影响。美国和欧洲的双盲对照研究证实了最初的说法。副作用仅限于可变的刺激性反应（干燥、紧绷、红斑），随着治疗皮肤的适应，这种反应会消退。医生必须告知患者要有现实的期望；维甲酸不能替代整形手术。维甲酸是治疗方案的核心，该方案包括定期使用防晒霜和保湿霜，同时避免有害行为，如吸烟、使用磨砂膏和过度清洗。
