Huang Qinhua, Campo Marino A, Yao Tuanli, Tian Qingping, Larock Richard C
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
J Org Chem. 2004 Nov 26;69(24):8251-7. doi: 10.1021/jo048788h.
Novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C-H activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed C-H activation reactions parallel electrophilic aromatic substitution.
已开发出用于合成复杂稠合多环的新型钯迁移/芳基化方法，其中采用了一个或多个涉及C-H活化的连续钯催化分子内迁移过程。该化学方法对富电子芳烃效果最佳，这与这些钯催化的C-H活化反应类似于亲电芳香取代的观点一致。
