Maehara Y, Orita H, Okuyama T, Moriguchi S, Tsujitani S, Korenaga D, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Br J Surg. 1992 Mar;79(3):245-7. doi: 10.1002/bjs.1800790320.
Data were analysed on 396 patients with early gastric cancer who underwent resection in this department; special reference was made to lymph node metastasis. Metastases were present in the dissected lymph nodes of 47 patients (11.9 per cent). The survival rate for patients with metastasis to lymph nodes was lower than for those without such metastasis (P less than 0.05). Lymph node metastasis was associated with larger tumour, a higher incidence of submucosal invasion, a higher rate of lymphatic vessel involvement, an advanced stage of disease and a non-curative resection rate of 6.4 per cent. Multivariate analysis showed that the independent risk factors for lymph node metastasis in patients with early gastric cancer were large tumour size, lymphatic vessel involvement and invasion into the submucosal layer. In patients with these risk factors, lymph node dissection and postoperative adjuvant therapy should be performed in an attempt to prevent recurrence in the form of lymph node metastasis.
对在本科室接受手术切除的396例早期胃癌患者的数据进行了分析；特别关注了淋巴结转移情况。47例患者（11.9%）的切除淋巴结中存在转移。有淋巴结转移患者的生存率低于无此类转移的患者（P<0.05）。淋巴结转移与肿瘤较大、黏膜下侵犯发生率较高、淋巴管受累率较高、疾病分期较晚以及6.4%的非根治性切除率相关。多因素分析表明，早期胃癌患者发生淋巴结转移的独立危险因素为肿瘤体积大、淋巴管受累和侵犯至黏膜下层。对于有这些危险因素的患者，应进行淋巴结清扫和术后辅助治疗，以试图预防以淋巴结转移形式出现的复发。
